Article Text

Download PDFPDF
Research paper
Extensive cerebral microbleeds predict parenchymal haemorrhage and poor outcome after intravenous thrombolysis
  1. Shenqiang Yan1,
  2. Xinchun Jin1,
  3. Xuting Zhang1,
  4. Sheng Zhang1,
  5. David S Liebeskind2,
  6. Min Lou1
  1. 1Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
  2. 2University of California-Los Angeles Stroke Center, Los Angeles, California, USA
  1. Correspondence to Dr Min Lou, Department of Neurology, the 2nd Affiliated Hospital of Zhejiang University, School of Medicine, #88 Jiefang Road, Hangzhou 310009, China; loumingxc{at}


Purpose Thrombolysis-related haemorrhagic transformation (HT) subtypes may have different prognostic implications. We aimed to analyse the impact of cerebral microbleeds (CMBs) burden on HT subtypes and outcome after intravenous thrombolysis.

Methods We retrospectively examined clinical and radiological data from 333 consecutive patients with acute ischaemic stroke who underwent susceptibility-weighted imaging before intravenous thrombolysis. Logistic regression analysis was used to determine the impact of CMBs on HT subtypes and neurological outcome.

Results We observed 596 CMBs in 119 (39.7%) patients on initial gradient-recalled echo scans. HT occurred in 88 (29.3%) patients, among which 62 were haemorrhagic infarction and 26 were parenchymal haemorrhage (PH). Logistic regression analysis indicated that the presence of extensive (≥3) CMBs was independently associated with PH (OR 6.704; 95% CI 2.054 to 21.883; p=0.002) and poor clinical outcome (OR 2.281; 95% CI 1.022 to 5.093; p=0.044).

Conclusions The presence of extensive (≥3) CMBs increased the risk of PH 24 h after intravenous thrombolysis, and predicted poor clinical outcome independently.

  • MRI

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.