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Contributors J-WH, HJK and S-HK took part in study concept and design. J-WH, HJK and S-HK were involved in drafting of the manuscript. J-WH, HJK, S-HK, IHJ and SHL participated in acquisition, analysis and interpretation of data. J-WH, HJK and S-HK were involved in statistical analysis. J-WH, HJK and S-HK took part in critical revision of the manuscript for important intellectual content.
Competing interests HJK has given talks, consulted and received honoraria from Bayer Schering Pharma, Biogen Idec, Genzyme, Merck Serono, Novartis, Teva-Handok and UCB and received research grants from Genzyme, Kael-GemVax and Merck Serono. He serves on a steering committee for MedImmune and is an editoral board member for Multiple Sclerosis Journal—Experimental, Translational and Clinical.
Ethics approval Institutional Review Board of National Cancer Centre.
Provenance and peer review Not commissioned; externally peer reviewed.