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ABN abstracts 2015 ABN Annual Meeting, 10 September 2015, Institute of Education, London
Thur 21, Parallel session 5: Therapeutics
108
REGIONAL EFFICACY OF NATALIZUMAB TREATMENT IN RELAPSING-REMITTING MULTIPLE SCLEROSIS (RRMS)
  1. Anisha Doshi1,
  2. Zanna Voysey1,
  3. Eva Bunting1,
  4. Muzaffar Malik2,
  5. Waqar Rashid1
  1. 1Hurstwood Park Neuroscience Centre, Princess Royal Hospital, Brighton and Sussex University Trust
  2. 2University of Brighton, Division of Medical Education

Abstract

Natalizumab is an established treatment for highly active Relapsing-Remitting Multiple Sclerosis (RRMS). Two-year efficacy in the AFFIRM trial showed No Evidence of Disease Activity(NEDA) – no relapses, no disability progression, no new MRI lesions – in 37% of patients compared with 7% in the placebo group. NEDA is increasingly used as a treatment goal in RRMS.

Methodology We performed a retrospective analysis of Natalizumab treatment in RRMS patients in our centre. We assessed the proportion of patients achieving NEDA in a typical clinical setting with at least 1 year treatment duration and analysed for predictors of response.

Results Mean age was 41.44 (13–62), 77% (51) of patients were female. 56 out of 66 patients had been on Natalizumab for >1year and were analysed. 55.36% patients achieved NEDA at 1 year. No statistically significant predictors (age, gender, starting disability and relapse rate) of response were identified.

Discussion The data confirms in a typical UK clinical setting good treatment response was achieved in highly active RRMS patients using Natalizumab. No additional factors were found which could predict treatment response suggesting within the limitations of power and length of this study that Natalizumab is effective in a broad range of highly active RRMS patients.

https://doi.org/10.1136/jnnp-2015-312379.108

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