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Meta-analysis of modifiable risk factors for Alzheimer's disease
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  • Published on:
    Meta-analysis by Xu et al. suffers from critical errors

    The meta-analysis by Xu et al is a valiant effort to map the evidence for modifiable risk factors of Alzheimer's disease (AD) (1). We acknowledge this huge effort, however, we have serious concerns regarding the systematic appraisal and the synthesis of the available data.

    On top of the critique by Drs. Wu and Brayne (e-letter), a comprehensive assessment of the article and its results can reveal critical error...

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    Conflict of Interest:
    None declared.
  • Published on:
    Comments on "Meta-analysis of modifiable risk factors for Alzheimer's disease"

    The meta-analysis by Xu et al., (2015)[1] reviews over 300 papers and identified 93 modifiable risk factors for Alzheimer's disease. Among these risk factors, population attributable risks (PAR) of nine important factors were estimated to contribute to up to 66% of Alzheimer's disease cases globally. We acknowledge the great effort of this massive review but there are some substantial analytical issues which should be highl...

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    Conflict of Interest:
    None declared.