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The corpus callosum in the diagnosis of multiple sclerosis and other CNS demyelinating and inflammatory diseases
  1. Nidhi Garg1,
  2. Stephen W Reddel1,
  3. David H Miller2,
  4. Jeremy Chataway2,
  5. D Sean Riminton1,
  6. Yael Barnett3,4,
  7. Lynette Masters5,
  8. Michael H Barnett4,6,
  9. Todd A Hardy1,6
  1. 1Neuroimmunology Clinic, Concord Hospital and University of Sydney, Sydney, New South Wales, Australia
  2. 2Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK
  3. 3Department of Radiology, St Vincent's Hospital, Sydney, New South Wales, Australia
  4. 4Sydney Neuroimaging Analysis Centre, Sydney, New South Wales, Australia
  5. 5Department of Neuroradiology, Southern Radiology, Miranda, Australia
  6. 6Brain & Mind Research Institute, University of Sydney, New South Wales, Australia
  1. Correspondence to Dr Todd A Hardy, Neuroimmunology Clinic, Department of Neurology, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW 2139, Australia; thardy{at}


Lesions in the corpus callosum (CC) are important radiological clues to the diagnosis of multiple sclerosis (MS), but may also occur in other neuroinflammatory and non-neuroinflammatory conditions. In this article, we discuss the radiological features of lesions within the CC in MS and other central nervous system inflammatory and acquired demyelinating diseases. An understanding of the appearance and location of lesions in the CC is important not only for accurate diagnosis and treatment of these various conditions, but as it also provides insights into pathogenesis.

  • MRI

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