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TRPV1, CGRP and SP in scalp arteries of patients suffering from chronic migraine. Some like it hot! Chronic migraine increases TRPV1 receptors in the scalp
  1. Stephen D Silberstein
  1. Correspondence to Dr Stephen D Silberstein, Jefferson Headache Center, Thomas Jefferson University, 900 Walnut Street, Suite 200, Philadelphia, PA 19107, USA; Stephen.silberstein{at}

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The transient receptor potential vanilloid type-1 receptor (TRPV1) is a non-selective, ligand-gated cation channel expressed in small sensory neurons.1 It responds to noxious heat, protons and capsaicin and it is preferentially expressed in small sensory neurons.2 ,3 Trigeminal nociceptive neurons contain glutamate, substance P (SP) and calcitonin gene-related peptide …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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