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Research paper
Destruction of paranodal architecture in inflammatory neuropathy with anti-contactin-1 autoantibodies
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  • Published on:
    Pathogenesis of anti-contactin-1 associated paranodopathy

    We thank Drs. Yuki and Wong for their interest in our paper. We agree that the finding that anti-CNTN1 autoantibodies in patients are mostly of the IgG4 subtype is important for our understanding of the pathophysiology of anti-CNTN1-associated neuropathy. However, in the study by Miura as well as in our study, IgG2 and IgG3 autoantibodies were detected in some patients (1, 2). The two patients from our study with predomina...

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    Conflict of Interest:
    None declared.
  • Published on:
    Sensory Ataxia and Anti-contactin-1 IgG4-Associated Paranodopathy
    • Nobuhiro Yuki, Nobuhiro Yuki
    • Other Contributors:
      • Anna Hiu Yi Wong

    With interest, we read an excellent paper written by a German group, in which four patients with chronic inflammatory demyelinating polyneuropathy (CIDP) carried IgG autoantibodies against contactin-1 (CNTN1) expressed at the paranodes in the peripheral nerves.[1] Human IgG antibodies consist of four subclasses (IgG1-4) with different structural and functional characteristics. IgG4 are generally believed to be non- infla...

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    Conflict of Interest:
    None declared.