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A nationwide survey of combined central and peripheral demyelination in Japan
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  • Published on:
    IgG subclass in combined central and peripheral demyelination associated with anti-neurofascin 155 antibodies
    • Nobuhiro Yuki, Nobuhiro Yuki
    • Other Contributors:
      • Anna Hiu Yi Wong

    At paranodes of both central and peripheral nerves, neurofascin-155 (NF155) is expressed by the terminal loops of myelin and associates with the axonal cell adhesion molecules contactin-1 and contactin-associated protein-1. They are important in maintaining the integrity of axo-glial junction and forming barrier against lateral diffusion of nodal channels. Human IgG antibodies consist of four subclasses (IgG1-4) with dif...

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    Conflict of Interest:
    None declared.