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Contributors QL, L-yC and XZ contributed to the conception and design of the study. QL, FL, BC, CXL, XNG, RRW, MSL and XGL contributed to the acquisition and analysis of data. QL, FL, XZ and L-yC contributed to the drafting of the manuscript and figures.
Funding This study was supported by the Beijing Municipal Science and Technology Commission (grant number Z151100003915078) and the National Natural Science Foundation of China (NSFC) (grant number 81230015).
Competing interests None declared.
Patient consent Obtained.
Ethics approval The study was approved by the Institutional Ethical Review Board.
Provenance and peer review Not commissioned; externally peer reviewed.
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