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  1. Rimona S Weil,
  2. Katerina Pappa,
  3. Hannah Burn,
  4. Ivanna Pavisic,
  5. Sam Schwarzkopf,
  6. Jason Warren,
  7. Huw Morris
  1. University College London


Aim To measure changes in visuo-perceptual processing in patients with Parkinson's disease without dementia.

Methods Images of cats and dogs that had been skewed by varying amounts were shown to patients with idiopathic Parkinson's disease (defined by QSBB criteria) (n=16) and healthy controls (n=11). Mean disease duration was 4 years (Standard deviation 3 years). Average L-DOPA equivalent dose was 554 mg (SD 487 mg). On each trial, participants were asked to identify the presented animal to generate psychophysical curves of skew against correctness and determine the threshold for identifying the correct animal. Visual acuity, UPDRS-scores and neuropsychology performance was measured for each participant.

Results Patients with Parkinson's disease, but without dementia, showed impaired ability to identify images that had been skewed, compared with healthy controls. The threshold for detection in patients was 61.2 degrees (SD 7.1 degrees), compared with 67.9 degrees (SD 2.1 degrees) in healthy participants, W=143, p=0.0056. The groups did not differ in visual acuity or neuropsychological performance.

Conclusions We show subtle but definite impairment of complex visual processing in the initial phases of Parkinson's disease in patients without overt cognitive impairment. This work has important implications for understanding the diagnosis, biology and progression of Parkinson's disease.

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