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Guidelines on PML risk stratification and diagnosis in patients with MS treated with natalizumab: so far so good?
  1. Mike P Wattjes1,2,
  2. Clemens Warnke3
  1. 1MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
  2. 2Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
  3. 3Department of Neurology, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany
  1. Correspondence to Dr Mike P Wattjes, Department of Radiology & Nuclear Medicine, MS Center Amsterdam, VU University Medical Center, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands; m.wattjes{at}

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Natalizumab is the cutting-edge drug for relapsing multiple sclerosis (MS) and the first registered monoclonal antibody in the field. The convincing efficacy on clinical and MRI outcome measures created new expectations, such as ‘freedom of disease activity’. Nonetheless, the beneficial effects are contrasted with the risk of developing potentially highly disabling or even fatal JC virus (JCV)-associated progressive multifocal leukoencephalopathy (PML) during therapy. As such, the benefits need to be weighed with the risks.

Expert opinion can aid clinicians and patients in such situations. In their JNNP paper, an expert panel led by McGuigan et al1 present the UK and Ireland guidelines for stratification and monitoring the risk of natalizumab-associated PML. The article provides suggestions, regarding regular monitoring using MRI, on frequency and interpretation …

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  • Correction notice This article has been corrected since it was published Online First. Details of reference 1 have been updated.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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