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Neurological picture
FDG-PET findings in three cases of Mills’ syndrome
  1. Koen Van Laere1,
  2. Guido Wilms2,
  3. Philip Van Damme3,4,5
  1. 1Department of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium
  2. 2Department of Radiology, University Hospitals Leuven, Leuven, Belgium
  3. 3Department of Neurology, University Hospitals Leuven, Leuven, Belgium
  4. 4Department of Neurosciences, KU Leuven—University of Leuven, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium
  5. 5Laboratory of Neurobiology, VIB, Vesalius Research Center, Leuven, Belgium
  1. Correspondence to Professor Philip Van Damme, Neurology Department, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium; philip.vandamme{at}uzleuven.be

https://doi.org/10.1136/jnnp-2014-309952

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    Primary lateral sclerosis (PLS) is a rare subtype of motor neuron disease that exclusively affects upper motor neurons, usually beginning in the lower limbs and, less frequently in the bulbar region or the upper limbs.1 In contrast to amyotrophic lateral sclerosis (ALS), PLS typically has a symmetrical presentation and this characteristic was part of the initially proposed PLS criteria.2 We report 18-fluorodeoxyglucose-positron-emission tomography (FDG-PET) findings in three cases with an asymmetrical subtype of PLS, more commonly known as Mills’ syndrome.3 There is no universally accepted definition of Mills’ syndrome, but it is mostly referred to as a slowly progressive motor syndrome with unilateral or asymmetrical pyramidal signs.4 In this …

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