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Contributors RH designed the study, collected and analysed the data, and drafted the manuscript. PK, SF, RS, MK, CP and RG designed the study, collected and analysed the data, and revised the manuscript. AC designed the study, collected and analysed the data, and drafted and revised the manuscript.
Competing interests RH received research and travel grants from BiogenIdec and travel grants from Novartis.SF received travel grants from BiogenIdec. RG declares speaker's and board honoraria from BiogenIdec, Baxter, BayerSchering, Chugai Pharmaceuticals, MerckSerono, Novartis, Roche, Sanofi-Aventis, Talecris and TEVA. He also received scientific grant support from BiogenIdec, BayerSchering, Genzyme, MerckSerono and TEVA. AC received personal compensation as a speaker or consultant for Bayer Schering, Biogen Idec, Genzyme, Merck Serono, Novartis, Sanofi-Aventis, UCB and Teva Neuroscience. AC received research support from the German Ministry for Education and Research (BMBF, German Competence Network Multiple Sclerosis (KKNMS; 01GI0914)), Biogen Idec, Genzyme and Novartis.
Ethics approval The ethics committee of Ruhr University Bochum (No. 4566-13).
Provenance and peer review Not commissioned; internally peer reviewed.