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Migraine and its psychiatric comorbidities
  1. Mia Tova Minen1,
  2. Olivia Begasse De Dhaem2,
  3. Ashley Kroon Van Diest3,
  4. Scott Powers4,
  5. Todd J Schwedt5,
  6. Richard Lipton6,
  7. David Silbersweig7
  1. 1Department of Neurology, NYU Langone Medical Center, New York, New York, USA
  2. 2Department of Internal Medicine, NYU Langone Medical Center, New York, New York, USA
  3. 3Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Medical Center, Cincinnati, Ohio, USA
  4. 4Cincinnati Children's Medical Center, Headache Center, Office for Clinical and Translational Research, Center for Child Behavior and Nutrition Research and Training, Pediatrics, Cincinnati, Ohio, USA
  5. 5Department of Neurology, Mayo Clinic, Phoenix, USA
  6. 6Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA
  7. 7Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA
  1. Correspondence to Dr Mia Tova Minen, Department of Neurology, NYU Langone Medical Center, 240 East 38th Street 20th floor, New York, NY 10016, USA; minenmd{at}


Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. In this manuscript, we provide an overview of the link between migraine and several comorbid psychiatric disorders, including depression, anxiety and post-traumatic stress disorder. We present data on psychiatric risk factors for migraine chronification. We discuss the evidence, theories and methods, such as brain functional imaging, to explain the pathophysiological links between migraine and psychiatric disorders. Finally, we provide an overview of the treatment considerations for treating migraine with psychiatric comorbidities. In conclusion, a review of the literature demonstrates the wide variety of psychiatric comorbidities with migraine. However, more research is needed to elucidate the neurocircuitry underlying the association between migraine and the comorbid psychiatric conditions and to determine the most effective treatment for migraine with psychiatric comorbidity.


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