L18 Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

Carlo Breda; Korrapati V Sathyasaikumar; Shama Sograte Idrissi; Francesca M Notarangelo; Jasper G Estranero; Gareth GL Moore; Edward W Green; Charalambos P Kyriacou; Robert Schwarcz; Flaviano Giorgini

doi:10.1136/jnnp-2016-314597.273

Article info

Experimental Therapeutics – Preclinical

L18 Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

Authors

Carlo Breda 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles
Korrapati V Sathyasaikumar 2Maryland Psychiatric Research Centre, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Shama Sograte Idrissi 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles
Francesca M Notarangelo 2Maryland Psychiatric Research Centre, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Jasper G Estranero 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles
Gareth GL Moore 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles
Edward W Green 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles
Charalambos P Kyriacou 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles
Robert Schwarcz 2Maryland Psychiatric Research Centre, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA PubMed articles Google scholar articles
Flaviano Giorgini 1Department of Genetics, University of Leicester, University Road, Leicester, UK PubMed articles Google scholar articles

Citation

Breda C, Sathyasaikumar KV, Idrissi SS, et al

L18 Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites

Journal of Neurology, Neurosurgery & Psychiatry 2016;87:A96.

Publication history

First published September 13, 2016.

Online issue publication

September 13, 2016

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