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Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort
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  • Published on:
    Re:Accumulation of MRI Markers of Cerebral Small Vessel Disease in Depression
    • Xin Xu
    • Other Contributors:
      • Christopher Chen

    We agree that an evaluation of the total cerebrovascular disease (CeVD) burden is important to understand the effect of brain structural abnormalities on clinical outcomes such as cognitive impairment and neuropsychiatric disorders. Recently, integrated measures of total brain MRI burden have been employed to understand neuropathological changes in elderly. However, global CeVD burden may not be best measured by the sim...

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    Conflict of Interest:
    None declared.
  • Published on:
    Accumulation of MRI Markers of Cerebral Small Vessel Disease in Depression

    In a study published in J Neurol Neurosurg Psychiatry, Xu et al.1 aimed to investigate the relation between microbleeds (CMBs) and Neuropsychiatric symptoms (NPS) in an elderly population, through a cross- sectional study related to 802 participants. Interestingly, they found a statistically significant increment of the incidence of depression, with the presence of multiple CMBs, in particular lobar CMBs. This finding is...

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    Conflict of Interest:
    None declared.