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Detecting dysexecutive syndrome in neurodegenerative diseases: are we using an appropriate approach and effective diagnostic tools?
  1. Michele Poletti1,
  2. Marco Cavallo2,3,
  3. Mauro Adenzato4,5
  1. 1Child and Adolescent Psychiatry Unit, Department of Mental Health and Pathological Addiction, Azienda Unità Sanitaria Locale, Reggio Emilia, Italy
  2. 2eCampus University, Novedrate, Italy
  3. 3Azienda Sanitaria Locale Torino 3, Collegno, Italy
  4. 4Department of Psychology, Center for Cognitive Science, University of Turin, Turin, Italy
  5. 5Neuroscience Institute of Turin, Turin, Italy
  1. Correspondence to Mauro Adenzato, Center for Cognitive Science, Department of Psychology, University of Turin, via Po 14, Turin 10123, Italy; mauro.adenzato{at}

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The term ‘dysexecutive syndrome’ refers to a dysregulation of executive functions and is strictly associated to frontal lobe damage. Dysexecutive syndrome typically encompasses emotional, motivational and behavioural symptoms, as well as cognitive deficits.1 This disabling condition can be observed in various clinical domains, and above all characterises degenerative diseases such as frontotemporal dementia (FTD) and—to a lesser degree—corticobasal degeneration (CBD).

In recent years, neuropsychological tools have been used to investigate dysexecutive syndrome.2 However, to date this field of clinical research suffers from a significant paradox: while clinicians and caregivers perceive with ease the presence of the symptoms that characterise patients' clinical picture, surprisingly it has not yet been possible to …

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  • Funding MA was supported by an MIUR grant (FIRB 2012–2017, protocol number: RBFR12F0BD_001) and by the University of Torino (Ricerca scientifica finanziata dall'Università ‘Cognizione sociale e attaccamento in popolazioni cliniche e non cliniche)’.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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