Article Text

Download PDFPDF
Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury
  1. Samira Saadoun,
  2. Suliang Chen,
  3. Marios C Papadopoulos
  1. Academic Neurosurgery Unit, St. George's University of London, London, UK
  1. Correspondence to Professor Marios C Papadopoulos, Department of Neurosurgery, St. George's Hospital, London SW17 0QT, UK; mpapadop{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


In the UK, blood pressure management after acute, severe traumatic spinal cord injury (TSCI) is variable.1 The American Association of Neurological Surgeons (AANS) recommends maintaining mean arterial pressure (MAP) at 85–95 mm Hg for a week after injury, but with little supporting evidence.2 To rationalise blood pressure management, we monitored intraspinal pressure (ISP) and spinal cord perfusion pressure (SCPP=MAP−ISP) from the injury site.3 Our technique is safe4 and analogous to monitoring intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in traumatic brain injury (TBI). The data indicate that, after TSCI, ISP rises and SCPP falls.3 Here we show strong correlation between high ISP or low SCPP and reduced neurological recovery. Our findings raise the possibility that interventions to reduce ISP or increase SCPP after TSCI may improve neurological outcome.


Patient recruitment

Approval for this observational cohort study was granted by the National Research Ethics Service London–St Giles Committee. Inclusion criteria are: (1) Severe TSCI defined as American spinal injuries association Impairment Scale (AIS) grade A, B or C; (2) Age 18–70 years; (3) Timing between TSCI and surgery within 72 hours. Exclusion criteria are: (1) Patients unable to consent; (2) Other major injuries or comorbidities; (3) Penetrating TSCI. Surgery and early management took place at St. George's Hospital. Consent was obtained by each patient.


Following bony realignment and posterior fixation, the ISP probe (Codman, Depuy Synthes, Leeds, UK) was tunnelled through …

View Full Text


  • Contributors MCP and SS designed the study, analysed data and wrote the paper. SC analysed data.

  • Funding Funded by Wings for Life Spinal Cord Research Foundation and Neurosciences Research Foundation (Fletcher fund).

  • Competing interests None declared.

  • Ethics approval Camberwell St Giles.

  • Provenance and peer review Not commissioned; externally peer reviewed.