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PO070 Treatment effect in visual snow
  1. Francesca Puledda1,
  2. Lau Tze1,
  3. Christoph Schankin2,
  4. Peter Goadsby1,3
  1. 1Department of Basic and Clinical Neuroscience, IOPPN, Kings College Hospital
  2. 2Department of Neurology, Inselspital University of Bern, Bern, Switzerland
  3. 3NIHR-Wellcome Trust King’s Clinical Research Facility, King’s College London


Patients with visual snow suffer from pan-field, dynamic visual disturbance. Proposed diagnostic criteria require at least two additional visual symptoms from: palinopsia, entoptic phenomena, photophobia and nyctalopia. Little is known regarding useful pharmacological treatments for patients. The aim of this study was to gain knowledge on the effect of a number of commonly used medications on visual snow. A questionnaire was prepared in collaboration with the patient group Eye-on-Vision and sent to subjects who had expressed an interest in research. It required to select from a list of drugs, including antiepileptics, antidepressants and benzodiazepines, the treatments that caused a change in symptoms, with either an improvement or a worsening. The study was approved by KCL Research Ethics Panel. For a total of n=182 patients, the effect of ninety-six drugs was recorded in 514 reports. Antidepressants and antiepileptics were the most commonly used drugs; they showed no effect on visual snow in 53% of reports. Visual snow is a highly disabling syndrome, for which there is no widely accepted treatment. More effort needs to be made in understanding its pathophysiology to allow focused treatment strategies.

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