Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials

Jordi Diaz-Manera; Roberto Fernandez-Torron; Jaume LLauger; Meredith K James; Anna Mayhew; Fiona E Smith; Ursula R Moore; Andrew M Blamire; Pierre G Carlier; Laura Rufibach; Plavi Mittal; Michelle Eagle; Marni Jacobs; Tim Hodgson; Dorothy Wallace; Louise Ward; Mark Smith; Roberto Stramare; Alessandro Rampado; Noriko Sato; Takeshi Tamaru; Bruce Harwick; Susana Rico Gala; Suna Turk; Eva M Coppenrath; Glenn Foster; David Bendahan; Yann Le Fur; Stanley T Fricke; Hansel Otero; Sheryl L Foster; Anthony Peduto; Anne Marie Sawyer; Heather Hilsden; Hanns Lochmuller; Ulrike Grieben; Simone Spuler; Carolina Tesi Rocha; John W Day; Kristi J Jones; Diana X Bharucha-Goebel; Emmanuelle Salort-Campana; Matthew Harms; Alan Pestronk; Sabine Krause; Olivia Schreiber-Katz; Maggie C Walter; Carmen Paradas; Jean-Yves Hogrel; Tanya Stojkovic; Shin’ichi Takeda; Madoka Mori-Yoshimura; Elena Bravver; Susan Sparks; Luca Bello; Claudio Semplicini; Elena Pegoraro; Jerry R Mendell; Kate Bushby; Volker Straub

doi:10.1136/jnnp-2017-317488

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Neuromuscular

Research paper

Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials

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Jordi Diaz-Manera Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Barcelona, Spain Neuromuscular Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain PubMed articles Google scholar articles
Roberto Fernandez-Torron Neuromuscular Area, Biodonostia Health Research Institute, Neurology Service, Donostia University Hospital, Donostia-San Sebastian, Spain The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Jaume LLauger Radiology Department, Universitat Autònoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain PubMed articles Google scholar articles
Meredith K James The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Anna Mayhew The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Fiona E Smith Magnetic Resonance Centre, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Ursula R Moore The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Andrew M Blamire Magnetic Resonance Centre, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Pierre G Carlier AIM & CEA NMR Laboratory, Institute of Myology, Pitié-Salpêtrière University Hospital, Paris, France PubMed articles Google scholar articles
Laura Rufibach The Jain Foundation, Seattle, Washington, USA PubMed articles Google scholar articles
Plavi Mittal The Jain Foundation, Seattle, Washington, USA PubMed articles Google scholar articles
Michelle Eagle The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Marni Jacobs Center for Translational Science, Division of Biostatistics and Study Methodology, Children’s National Health System, Washington, District of Columbia, USA Department of Pediatrics, Epidemiology and Biostatistics, George Washington University, Washington, District of Columbia, USA PubMed articles Google scholar articles
Tim Hodgson Magnetic Resonance Centre, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Dorothy Wallace Magnetic Resonance Centre, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Louise Ward Magnetic Resonance Centre, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Mark Smith Department of Radiology, Nationwide Children’s Hospital, Columbus, Ohio, USA PubMed articles Google scholar articles
Roberto Stramare Radiology Unit, Department of Medicine, University of Padova, Padova, Italy PubMed articles Google scholar articles
Alessandro Rampado Radiology Unit, Department of Medicine, University of Padova, Padova, Italy PubMed articles Google scholar articles
Noriko Sato Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan PubMed articles Google scholar articles
Takeshi Tamaru Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan PubMed articles Google scholar articles
Bruce Harwick Department of Radiology, CMC Mercy Charlotte, Carolinas Healthcare System Neurosciences Institute, Charlotte, North Carolina, USA PubMed articles Google scholar articles
Susana Rico Gala Department of Radiology, Hospital U. Virgen de Valme, Sevilla, Spain PubMed articles Google scholar articles
Suna Turk AIM & CEA NMR Laboratory, Institute of Myology, Pitié-Salpêtrière University Hospital, Paris, France PubMed articles Google scholar articles
Eva M Coppenrath Department of Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany PubMed articles Google scholar articles
Glenn Foster Center for Clinical Imaging Research CCIR, Washington University, St. Louis, Missouri, USA PubMed articles Google scholar articles
David Bendahan Centre de Résonance, Magnétique Biologique et Médicale, Marseille, France Aix-Marseille Université, Marseille, France PubMed articles Google scholar articles
Yann Le Fur Aix-Marseille Université, Marseille, France PubMed articles Google scholar articles
Stanley T Fricke Department of Diagnostic Imaging and Radiology, Children’s National Health System, Washington, District of Columbia, USA PubMed articles Google scholar articles
Hansel Otero Department of Diagnostic Imaging and Radiology, Children’s National Health System, Washington, District of Columbia, USA PubMed articles Google scholar articles
Sheryl L Foster Department of Radiology, Westmead Hospital, Westmead, New South Wales, Australia Faculty of Health Sciences, University of Sydney, Sydney, Australia PubMed articles Google scholar articles
Anthony Peduto Department of Radiology, Westmead Hospital, Westmead, New South Wales, Australia Faculty of Health Sciences, University of Sydney, Sydney, Australia PubMed articles Google scholar articles
Anne Marie Sawyer Lucas Center for Imaging, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Heather Hilsden The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Hanns Lochmuller The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Ulrike Grieben Charite Muscle Research Unit, Experimental and Clinical Research Center, A Joint Co-operation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany PubMed articles Google scholar articles
Simone Spuler Charite Muscle Research Unit, Experimental and Clinical Research Center, A Joint Co-operation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany PubMed articles Google scholar articles
Carolina Tesi Rocha Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
John W Day Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
Kristi J Jones Institute for Neuroscience and Muscle Research, Children’s Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Diana X Bharucha-Goebel Department of Neurology, Children’s National Health System, Washington, District of Columbia, USA National Institutes of Health (NINDS), Bethesda, Maryland, USA PubMed articles Google scholar articles
Emmanuelle Salort-Campana Neuromuscular and ALS Center, La Timone Hospital, Aix-Marseille Université, Marseille, France PubMed articles Google scholar articles
Matthew Harms Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA PubMed articles Google scholar articles
Alan Pestronk Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA PubMed articles Google scholar articles
Sabine Krause Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany PubMed articles Google scholar articles
Olivia Schreiber-Katz Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany PubMed articles Google scholar articles
Maggie C Walter Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany PubMed articles Google scholar articles
Carmen Paradas Neuromuscular Unit, Department of Neurology, Hospital U. Virgen del Rocío/Instituto de Biomedicina de Sevilla, Sevilla, Spain PubMed articles Google scholar articles
Jean-Yves Hogrel Institut de Myologie, AP-HP, G.H. Pitié-Salpêtrière, Paris, Île-de-France, France PubMed articles Google scholar articles
Tanya Stojkovic Institut de Myologie, AP-HP, G.H. Pitié-Salpêtrière, Paris, Île-de-France, France PubMed articles Google scholar articles
Shin’ichi Takeda Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan PubMed articles Google scholar articles
Madoka Mori-Yoshimura Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan PubMed articles Google scholar articles
Elena Bravver Neurosciences Institute, Carolinas Healthcare System, Charlotte, North Carolina, USA PubMed articles Google scholar articles
Susan Sparks Neurosciences Institute, Carolinas Healthcare System, Charlotte, North Carolina, USA PubMed articles Google scholar articles
Luca Bello Department of Neurosciences, University of Padova, Padova, Italy PubMed articles Google scholar articles
Claudio Semplicini Department of Neurosciences, University of Padova, Padova, Italy PubMed articles Google scholar articles
Elena Pegoraro Department of Neurosciences, University of Padova, Padova, Italy PubMed articles Google scholar articles
Jerry R Mendell Nationwide Children’s Hospital, Columbus, Ohio, USA PubMed articles Google scholar articles
Kate Bushby The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Volker Straub The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle upon Tyne, UK PubMed articles Google scholar articles
The Jain COS Consortium
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Correspondence to Professor Volker Straub, The John Walton Muscular Dystrophy Research Centre, MRC Centre for Neuromuscular Diseases, Newcastle Upon Tyne NE1 3BZ, UK; volker.straub{at}ncl.ac.uk

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Citation

Diaz-Manera J, Fernandez-Torron R, LLauger J The Jain COS Consortium, et al

Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials

Journal of Neurology, Neurosurgery & Psychiatry 2018;89:1071-1081.

Publication history

Received October 19, 2017
Revised March 2, 2018
Accepted March 26, 2018
First published May 7, 2018.

Online issue publication

March 02, 2020

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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