Rationale 50% of multiple sclerosis (MS) relapses result in permanent disability. Modelling recovery from relapse enables cost-effectiveness of interventions to be evaluated. The expanded disability status scale (EDSS) is cumbersome in clinical practice and may not reflect patient experience. The EQ-5D is a standardised measure of health status and a common currency used by agencies such as NICE.
Aim To compare measurable recovery from relapse using EDSS and EQ-5D.
Method EDSS and EQ-5D-3L were collected during clinician defined relapse and at 2 months follow-up, in 89 patients identified in a regional rapid access clinic.
Results Median EDSS in relapse was 5.0 and 3.5 at follow-up; 67 (75%) patients experienced improvement in EDSS. The proportion of patients with EQ-5D scores of level 1 (fewest symptoms) increased in all 5 domains at 2 months, although anxiety/depression was the most resistant to improvement. Of those with EDSS improvement, only 49 (73%) reported improvement in their health state (EQ-5D).
Conclusion EDSS improvement following relapse is not always accompanied by patient-reported improvement in health state (EQ-5D), which may be more effective in identifying ongoing health issues. Low-level discrepancies may also inform on the relative merit of EQ-5D versus EDSS in assessing recovery.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.