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Multimodal spinal cord MRI offers accurate diagnostic classification in ALS

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  • Contributors GQ had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. M-MEM, GQ and SD actively participated in the design of the study, in the preparation of MRI protocol and in the establishment of MRI acquisition settings. TL and P-FP selected patients with ALS to include in the study and performed clinical and diagnostic evaluation. MRI acquisition, imaging data treatment and analysis were performed by GQ, M-MEM and SD. Statistical analysis was performed by GQ. Critical revision of the manuscript for important intellectual content was done by GQ, P-FP and PB. P-FP and VM-P obtained funding for the study. P-FP, VM-P, SD and M-MEM were responsible for the administrative, technical or material support. P-FP did the supervision.

  • Funding This study was supported by the Association Française contre les Myopathies-Téléthon (AFM-Téléthon) and the Institut pour la Recherche sur la Moelle épinière et l’Encéphale (IRME). The research leading to these results has also received funding from the program ‘ Investissements d’Avenir’ ANR-10-IAIHU-06. PB is supported by the Health Research Board Ireland (HRB EIA-2017-019), the Irish Institute of Clinical Neuroscience IICN— Novartis Ireland Research Grant (IICN 2016), and the Iris O’Brien Foundation. GQ is supported by a PhD grant by the University of Padova (Italy).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethics Committee of Pitié-Salpetrière Hospital, Paris, France.

  • Provenance and peer review Not commissioned; externally peer reviewed.