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Mechanisms of poststroke fatigue
  1. William De Doncker1,
  2. Robert Dantzer2,
  3. Heidi Ormstad3,
  4. Annapoorna Kuppuswamy1
  1. 1 Institute of Neurology, University College London, London, UK
  2. 2 Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  3. 3 Faculty of Health and Social Sciences, University of South West Norway, Oslo, Norway
  1. Correspondence to Dr Annapoorna Kuppuswamy, University College London Institute of Neurology, London WC1N 3BG, UK; a.kuppuswamy{at}


Poststroke fatigue is a debilitating symptom and is poorly understood. Here we summarise molecular, behavioural and neurophysiological changes related to poststroke fatigue and put forward potential theories for mechanistic understanding of poststroke fatigue.

  • stroke

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  • Contributors AK conceptualised the review. All authors contributed equally to the writing of the review.

  • Funding Wellcome Trust (202346/Z/16/Z).

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.