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CSF β-amyloid and white matter damage: unravelling the neuropathology of Alzheimer’s disease
  1. Gilberto Sousa Alves
  1. Correspondence to Professor Gilberto Sousa Alves, Translational Psychiatry Research Group, Department of Internal Medicine, Federal University of Ceará, Fortaleza 60020-181, Brazil; gsalves123{at}

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White matter lesion load may be associated with lower CSF β-amyloid levels in Alzheimer’s disease (AD) subjects

The great advance of neuroimaging techniques witnessed in the last 10 years has enabled an intensive debate on the role of white matter (WM) lesions in the pathophysiology of AD. Once regarded by the early literature as a common result of cerebrovascular pathology, WM alterations, particularly those found in predementia stages, have been consistently linked to neurodegeneration processes by recent multimodal studies. One particular relevant issue is whether WM primary degeneration evolves independently from grey matter (GM) atrophy or occurs as a secondary product of cortical atrophy, as posited by the Wallerian degeneration hypothesis.1 2 The work from …

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