Footnotes

• Contributors NK participated in the design, enrolled patients, carried out and coordinated the study at the Nijmegen site and drafted the manuscript. NV and BP helped draft the manuscript. AP enrolled patients and coordinated the study at the Cleveland site. MN participated in the design and coordination of the study and helped draft the manuscript. MV and AM participated in the cardiopulmonary screening before physical fitness testing of the patients at the Nijmegen site. BB and JA wrote the grant application, conceived of the study and participated in its design and coordination and helped draft the manuscript. All authors read and approved the final manuscript.

• Competing interests None declared.

• Patient consent Obtained.

• Ethics approval CMO Arnhem-Nijmegen and Cleveland Clinic Institutional Review Board.

• Provenance and peer review Not commissioned; externally peer reviewed.