Article Text

Download PDFPDF
F58 Assessment scales for patients with advanced huntington’s disease: comparison of the UHDRS and UHDRS-FAP
  1. Jessica Y Winder1,
  2. Wilco P Achterberg2,3,
  3. Johan Marinus1,
  4. Sarah L Gardiner1,4,
  5. Raymund AC Roos1
  1. 1Department of Neurology, Leiden University Medical Center, ZA Leiden, The Netherlands
  2. 2Department of Public Health and Primary Care, Leiden University Medical Center, ZA Leiden, The Netherlands
  3. 3Huntington Center Topaz Overduin, SX Katwijk, The Netherlands
  4. 4Department of Human Genetics, Leiden University Medical Center, ZA Leiden, The Netherlands


Background The standard clinical assessment tool in Huntington’s disease is the Unified Huntington’s Disease Rating Scale (UHDRS). In patients with advanced Huntington’s disease ceiling and floor effects of the UHDRS hamper the detection of changes. Therefore, the UHDRS-For Advanced Patients (UHDRS-FAP) has been designed for patients with late stage Huntington’s disease.

Aims The aim of this cross-sectional study was to examine if the UHDRS-FAP can differentiate better between patients with advanced Huntington’s disease than the UHDRS.

Methods Forty patients, who were institutionalized or received day-care, were assessed with the UHDRS, UHDRS-FAP, and Care Dependency Scale (CDS). Severity of Huntington’s disease was defined by the Total Functional Capacity (TFC). Comparisons between consecutive TFC stages were performed for all domains of the UHDRS, UHDRS-FAP, and CDS using Mann-Whitney U tests.

Results The motor scores of the UHDRS-FAP and UHDRS were the only subscales with significantly worse scores in TFC stage 5 compared to stage 4. In TFC stages 4–5, the range of the UHDRS-FAP motor score was broader, the standard error of measurement was lower, and the effect size r was higher than for the UHDRS motor score. The CDS declined significantly across all TFC stages.

Conclusions Our results suggest that the UHDRS-FAP motor score differentiates better between patients with severe Huntington’s disease than the UHDRS motor score. Therefore, the UHDRS-FAP motor score is potentially a better instrument than the UHDRS motor score to improve disease monitoring and, subsequently, care in patients with advanced Huntington’s disease in long-term care facilities.

  • Advanced stage
  • Nursing home
  • Rating scales

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.