I01 QRX-704, a novel antisense oligonucleotide therapy, designed to prevent hd pathology while maintaining htt function

Pontus Klein; Zhana Karneva; Lodewijk Toonen; Hyeongju Kim; Nicholas Caron; Linda van der Graaf; Levi Buil; Geert van der Horst; Herma Anthonijsz; Frits van der Ham; Wouter Beumer; Michael Hayden; Ji-Joon Song; Willeke van Roon-Mom; Gerard Platenburg

doi:10.1136/jnnp-2018-EHDN.237

Article info

Experimental therapeutics – preclinical

I01 QRX-704, a novel antisense oligonucleotide therapy, designed to prevent hd pathology while maintaining htt function

Authors

Pontus Klein 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Zhana Karneva 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Lodewijk Toonen 2Department of Human Genetics, Leiden University Medical Center, RC Leiden, The Netherlands PubMed articles Google scholar articles
Hyeongju Kim 3Department of Biological Sciences, KAIST, Daejeon, Korea PubMed articles Google scholar articles
Nicholas Caron 4Centre for Molecular Medicine and Therapeutics (CMMT), CFRI, Department of Medical Genetics, University of British Columbia, Vancouver, Canada PubMed articles Google scholar articles
Linda van der Graaf 2Department of Human Genetics, Leiden University Medical Center, RC Leiden, The Netherlands PubMed articles Google scholar articles
Levi Buil 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Geert van der Horst 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Herma Anthonijsz 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Frits van der Ham 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Wouter Beumer 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles
Michael Hayden 4Centre for Molecular Medicine and Therapeutics (CMMT), CFRI, Department of Medical Genetics, University of British Columbia, Vancouver, Canada PubMed articles Google scholar articles
Ji-Joon Song 3Department of Biological Sciences, KAIST, Daejeon, Korea PubMed articles Google scholar articles
Willeke van Roon-Mom 2Department of Human Genetics, Leiden University Medical Center, RC Leiden, The Netherlands PubMed articles Google scholar articles
Gerard Platenburg 1ProQR Therapeutics, CK Leiden, The Netherlands PubMed articles Google scholar articles

Citation

Klein P, Karneva Z, Toonen L, et al

I01 QRX-704, a novel antisense oligonucleotide therapy, designed to prevent hd pathology while maintaining htt function

Journal of Neurology, Neurosurgery & Psychiatry 2018;89:A88.

Publication history

First published September 12, 2018.

Online issue publication

May 13, 2022

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