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High prevalence of electrocardiac abnormalities in anti-CASPR2 antibody-associated disease

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  • Contributors QL and HZG designed the study. QL contributed to data analysis and drafted the manuscript. JM collected patients’ materials and contributed to manuscript preparation. YH provided the important result of case observation. LYC offered advice and financial support on antibody tests. HTR performed antibody tests. QL, QLu, JYZ, BP and YZG evaluated patients and provided clinical information.

  • Funding This study was supported by CAMS innovation Fund for Medical Sciences (CIFMS, 2016-12M-1-002) and the National Key Research and Development Program of China (2016YFC0905100).

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Ethics approval Institutional review board of Peking Union Medical College Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice Since this paper was first published online, Hong Zhi Guan ( has been added as an additional corresponding author.