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CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics
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  • Published on:
    The utility of CSF biomarkers in idiopathic normal pressure hydrocephalus?
    • Halil Onder, Neurology Specialist Neurology Clinic, Yozgat City Hospital, Yozgat, Turkey, Telephone number: 3544442066

    Dear Editor,
    The original article by Jeppsson et al. provides substantial perspectives regarding the diagnostic
    significance of cerebrospinal fluid (CSF) biomarkers in discriminating patients with idiopathic normal pressure hydrocephalus (iNPH) from patients with other neurodegenerative disorders. 1 They have found that patients with iNPH had, compared with healthy individuals, lower concentrations of P-tau and APP-derived proteins in combination with elevated MCP-1 1. Moreover, compared with the non-iNPH disorders group, iNPH was characterized by the same significant change; low concentration of tau proteins and APP-derived proteins, and elevated MCP-1. I sincerely appreciate the authors for conducting such a large-scale study of a strictly interesting topic. However, I would like to make some comments hoping to provide a better understanding of some points and some perspectives to be kept in mind while planning future related studies
    In my opinion, the investigation of CSF biomarkers in patients with iNPH may provide several insights in addition to discriminating the iNPH patients from other neurodegenerative diseases. Certainly, these study results may give the opportunity to understand the unknown pathophysiological aspects of iNPH, thereby, even leading to new classifications of the disease. Actually, there may be many questions to be clarified regarding diagnostic approach, evaluation of the iNPH patients and even identification of the disease. 2,3...

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    Conflict of Interest:
    None declared.