Article Text

Download PDFPDF

Review
Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience
  1. Evan C Edmond1,2,3,4,
  2. Charlotte J Stagg1,2,3,4,
  3. Martin R Turner1,2,3,4
  1. 1 Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK
  2. 2 Wellcome Centre for Integrative Neuroimaging, Oxford University, Oxford, UK
  3. 3 Oxford Centre for Human Brain Activity (OHBA), Oxford University, Oxford, UK
  4. 4 Oxford Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK
  1. Correspondence to Professor Martin R Turner, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford OX3 9DU, UK; martin.turner{at}ndcn.ox.ac.uk

Abstract

The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.

  • als
  • motor neuron disease
  • electrical stimulation
  • magnetic stimulation
  • neurophysiology, expt
View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors Study concept and design: ECE, CJS, MRT. Data acquisition and analysis: ECE, MRT. Drafting and critical review of the manuscript: ECE, CJS, MRT. All three authors approved the version published and are accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.