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ZL and YH contributed equally.
Contributors Qiang Dong, Xin Wang, and Yangtai Guan contributed to the overall design of the study. Yong Hao, Shuai Wu, and Yan Han involved in sample collection. Desheng Zhu, and Mingyuan Liu undertook the statistical analysis and interpretation of data. Zezhi Li wrote the draft of the manuscript. All authors have contributed to approve the final manuscript.
Funding This study was funded by National Natural Science Foundation of China (81230027, 81771295), Shanghai Natural Science Foundation (15ZR1412900), Summit & Plateau Key Discipline Construction Foundation of Shanghai Education Commission (TM201508), Shanghai Medical Planning Commission's Clinical Special Project of Integrated Traditional Chinese and Western Medicine (ZHYY-ZXYJHZX-1-201701), Shanghai Jiao Tong University Medical Engineering Foundation (YG2015MS52, YG2016MS48). Pfizer, China partly sponsored the study.
Disclaimer All funding agencies for this study had no further role in study design, data analysis and in the decision to submit the paper for publication.
Competing interests None declared.
Patient consent for publication Obtained.
Ethics approval The study was approved by Institutional Review Boards of Zhongshan Hospital.
Provenance and peer review Not commissioned; internally peer reviewed.
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