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063 ‘Less contented as a person’: an update from the LGI1-QoL study
  1. Sophie Binks1,
  2. Michele Veldsman2,
  3. Saiju Jacob3,
  4. Paul Maddison4,
  5. Jan Coebergh5,
  6. M Isabel Leite1,
  7. Masud Husain1,
  8. Sarosh R Irani1
  1. 1Nuffield Department of Clinical Neurosciences, University of Oxford
  2. 2Department of Experimental Psychology, University of Oxford
  3. 3Dept of Neurology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust
  4. 4Dept of Neurology, Queen’s Medical Centre, Nottingham University Hospitals NHS Trust
  5. 5St Peter’s Hospital, Ashford and St Peter’s NHS Hospitals Foundation Trust


Objective To establish a detailed phenotype of LGI1-antibody patients long-term through a cognitive, neuropsychiatric and quality of life (QoL) battery, and relate outcomes to biochemical, clinical and genetic factors.

Methods 60 patients have now undergone detailed evaluation for the LGI1-QoL study, extending the previously-reported preliminary cohort. Selected assessments included domains clinically observed as impaired such as emotionality, fatigue and QoL.

Results Patients (40 male) aged 44–92 were assessed at a median of three years post-onset (range 4 months-15 years). Compared to published thresholds in age-appropriate healthy controls, 32% were impaired on the Addenbrooke’s Cognitive Examination-Revised, 39% on the Frontal Assessment Battery, 39–52% on two different fatigue scales, 43–51% on the two different measures of the carer-reported Neuropsychiatric Inventory Questionnaire, and 40% on the Life Satisfaction Questionnaire (LSQ) – Life as a Whole. LGI1-antibody patients were significantly (p≤0.05) more impaired on five LSQ sub-domains compared to an available dataset for healthy elders.

Analysis of retrospective pre- and post-illness analyses of LSQ, the EQ-5D-5L, another patient-related QoL measure, and the Modified Rankin Scale showed significant (p≤0.01) decreases in most domains. Further clinical and paraclinical correlations will be presented.

Conclusions Many LGI1-antibody patients demonstrate sustained deficits across cognitive, neuropsychiatric, carer-reported and QoL domains.

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