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128 Efficacy and safety of deep brain stimulation in Parkinson’s disease: systematic review and meta-analysis
  1. Sosipatros Bratsos,
  2. Dimitrios Karponis,
  3. Sohag Saleh
  1. Imperial College London


Background Deep brain stimulation (DBS) is a neurosurgical procedure indicated in patients with advanced Parkinson’s disease (PD). This systematic review and meta-analysis aimed to investigate the efficacy and safety of DBS in comparison to best medical therapy (BMT) in the treatment of PD.

Methods A systematic search was performed in Medline, Embase and Central. Randomised controlled trials (RCTs) comparing DBS to BMT in PD patients were included. Outcome measures were impairment/disability (UPDRS), quality of life (PDQ-39), levodopa equivalent dose (LED) and rates of serious adverse events (SAE).

Results Eight eligible RCTs (n=1189) were included in the meta-analysis. Regarding efficacy outcomes, there were significant improvements in UPDRS, PDQ-39 and LED in favour of DBS (P<0.00001). The risk of SAE was significantly higher in the DBS group (P=0.005), as was the total number of SAE (P<0.0018).

Conclusions Overall, DBS was found superior to BMT at improving impairment/disability, quality of life and reducing medication doses, but these benefits need to be weighed against the higher risk of SAE.

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