Introduction The TYSABRI Observational Program (TOP) is the largest real-world study in natalizumab-treated relapsing-remitting MS patients. Country-specific data, alongside global data, can provide information on natalizumab’s effectiveness in local practice.
Methods Annualised relapse rate (ARR) and cumulative probability of 24-week confirmed disability worsening (CDW; Expanded Disability Status Scale [EDSS] score increase from baseline of ≥1.5 from 0.0, ≥1.0 from 1.0–5.5, or ≥0.5 from ≥6.0) and improvement (CDI; decrease ≥1.0 from baseline EDSS score ≥2.0) over 6 years were analysed in TOP UK (n=134) and global (N=6149) cohorts using data from July 2007 to November 2017.
Results ARR decreased in UK patients from 2.21 in the year before initiation to 0.21 on natalizumab, paralleling the global decrease from 1.99 to 0.21. At 6 years, probabilities of CDW and CDI were, respectively, 27.8% and 34.4% in UK patients and 24.2% and 32.0% globally.
Conclusions Consistent with global TOP results, natalizumab ARRs and disability worsening rates remained low and disability improvement rates exceeded 30% at 6 years in the UK cohort. These results support natalizumab’s long-term effectiveness in real-world settings.
Support: Biogen. Disclosures will be included on the poster.
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