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269 Prevention of hypertensive injury to the brain by intensive treatment in intracerebral haemorrhage (PROHIBIT-ICH): protocol for a randomised controlled trial of telemetric home BP monitoring
  1. Iain McGurgan1,
  2. Shahena Butt2,
  3. Louise Silver1,
  4. David Werring2,
  5. Peter Rothwell1
  1. 1Nuffield Department of Clinical Neurosciences, University of Oxford
  2. 2Stroke Research Centre, UCL Institute of Neurology


Background Intracerebral haemorrhage (ICH) accounts for about 10% of strokes in the UK and is a major cause of severe disability and death. Sustained post-acute blood pressure (BP) management arguably holds the most potential to improve long-term prognosis, but there have been no trials to guide the optimal strategy for BP lowering after ICH. Telemetric home BP monitoring is a promising intervention to improve control.

Methods 112 adult survivors of hypertension-related ICH across multiple UK sites will be randomised to intensive telemetric home BP monitoring-guided treatment (intervention) to achieve a target of <120/80 mmHg or standard care (control).


  1. Efficacy: the magnitude of difference in BP at 3 months in the intervention arm versus the control arm compared with baseline measures

  2. Feasibility: consent rate; dropout rate from the intervention prior to 1 month; patient approval of the monitoring process

  3. Safety: serious adverse events related to reducing BP in the intervention arm

Conclusion The BP monitoring component of PROHIBIT-ICH will determine whether a strategy of intensive BP treatment guided by telemetric monitoring for an extended period of time after spontaneous ICH is feasible, safe and effective in reducing BP.

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