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Prodromal muscle cramps predict rapid motor functional decline in amyotrophic lateral sclerosis
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Footnotes
Contributors KS and SK designed the study. KS, SM, YS, MB, HA, TS, YS and AT collected clinical data. KS and SK drafted the manuscript. KS performed statistical analyses. SK supervised the study.
Funding KS, SM, YS and SK receive research support from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. SK receives Grants-in-Aid from the Research Committee of CNS Degenerative Diseases, the Ministry of Health, Labour and Welfare of Japan.
Competing interests None declared.
Patient consent Not required.
Ethics approval This study was approved by the Ethics Committee of Chiba University School of Medicine.
Provenance and peer review Not commissioned; externally peer reviewed.