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XG and CL contributed equally.
Contributors XG, CL and H-FS designed the study. XG, CL and YC performed the experiments and data analysis. XG and CL wrote the manuscript and H-FS revised the manuscript. QW, BC, RO, XY, YH, LZ, HL, YW, WS, BZ and XC collected clinical information for all the participants.
Funding This work was supported by the National Science Fund of China (grant no 81571247) and the National Key Research and Development Program of China (grant no 2016YFC0901504).
Competing interests None declared.
Patient consent Not required.
Ethics approval The study was approved by the Ethics Committee of Sichuan University.
Provenance and peer review Not commissioned; externally peer reviewed.
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