Footnotes

• Contributors I have personally written this commentary.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests In the last 5 years Professor GG has received compensation for participating on Advisory Boards in relation to clinical trial design, trial steering committees and data and safety monitoring committees from: Abbvie, Actelion, Atara Bio, Biogen, Celgene, Genzyme-Sanofi, Genentech, GSK, Merck-Serono, Novartis, Roche, Synthon BV and Teva.

• Patient consent Not required.

• Provenance and peer review Commissioned; internally peer reviewed.