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Contributors BL, PBJ, MSZ and AJC designed the study. All authors contributed to data collection, analysis and interpretation. All authors have approved the final version of the manuscript and are accountable for the accuracy and integrity of the data.
Funding The study was funded by The Stanley Medical Research Institute (14T-004).
Competing interests None declared.
Patient consent Parental/guardian consent obtained.
Ethics approval South Central – Oxford C Research Ethics Committee (REC reference 15/SC/0219).
Provenance and peer review Not commissioned; externally peer reviewed.
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