Objectives To assess the outcomes in patients>60 years with traumatic brain injury (TBI) and determine if there is an age cut-off for worse prognosis.
Design Single centre retrospective study. Data collected as part of TrIBAL study.
Subjects All patients with TBI admitted to our hospital over a 4 month period.
Methods Patients were divided into 6 groups based on their age; group 0 included patients<60 years, 60≤Group 1<65, 65≤Group 2<70, 70≤Group 3<75, 75≤Group 4<80 and Group 5>80. Data was collected on various factors that influence outcomes in TBI patients including presenting GCS, hypotension, hypoxia, antithrombotic therapy and Marshall CT score. Glasgow outcome score (GOS) at discharge from hospital was used. A multinomial logistic regression analysis was performed.
Results Over the 4 month period 144 patients with TBI were admitted. There were no significant differences in baseline characteristics including presenting GCS and Marshall CT scores between the groups. The GOS at discharge was significantly worse only in Group 5 when Group 0 was considered as the base outcome (p<0.001). Groups 1 to 5 had a significant increased number of patients on antithrombotic therapy when compared with Group 0 (p<0.05). The adjusted analysis for GOS at discharge revealed the use of antithrombotic therapy in Group 5 was the only factor that influenced outcome (p=0.014).
Conclusions In this cohort, age >80 years was the cut off for worse prognosis. In this age group anticoagulation was the only factor we found that influenced outcome.
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