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WP1-5 Surgical management of spinal meningiomas and appraisal of possible association with oestrogen receptor positive breast carcinoma
  1. D Wang,
  2. AR Sadek,
  3. A Nader-Sepahi
  1. Wessex Neurological Centre, University Hospital Southampton, UK


Objectives Evaluation of the presentation, demographics, pathology and outcomes associated with surgical management of spinal meningiomas and review of an association with a history of preceding breast carcinoma.

Design A retrospective single-centre case series of surgically managed meningiomas over a 4 year period.

Subjects 184 cases of surgically managed intradural lesions from 2014 to 2018.

Results 48 patients were identified as having a spinal meningioma [26% of all spinal tumours]. 42 [88%] were female with a cumulative mean age of 69 years [SD ±10]. Most lesions were located in the thoracic spine [n=41]. The cohort had a Charlson comorbidity index of 3. Weakness [median MRC grade 3], neuropathic pain [mean NPS of 26/100] and problems with gait [median mJOA score of 2] were the commonest presenting symptoms. Post-operatively improvements in MRC, NPS, mJOA and SF36 scores were observed. 16% [n=7] of cases had a preceding history of oestrogen-receptor positive breast carcinoma, with a mean interval time between diagnoses of 8.1 years [SD ±5.1]. Risk analysis using baseline data from national cancer registries demonstrates that the likelihood of both diagnoses to be 4.9%, this is considerably lower than the observed 16% (p=0.01).

Conclusions Analysis of our cohort has demonstrated an association between a preceding diagnosis of oestrogen-receptor positive breast carcinoma and spinal meningiomas that cannot be explained by chance alone.

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