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HLA-DRB1*16:02 is a disease susceptibility allele for anti-NMDAR encephalitis in the Chinese Han population
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one of the major types of antibody-mediated autoimmune encephalitis. It was originally reported to be highly prevalent in young women with ovarian teratoma, but later studies found that the cases were not limited to young women with tumours; it was observed in both genders of any age, irrespective of tumour positivity.1 Clinical manifestations include neuropsychiatric syndrome with movement disorders, seizures and autonomic dysfunction.
Recently, several studies have reported human leucocyte antigen (HLA) associations with antibody-mediated encephalitis, including anti-NMDAR encephalitis and anti-leucine-rich glioma-inactivated1 (LGI1) encephalitis. While HLA-DRB1*07:01 or its extended …
Contributors Only NI is the author and no additional contributorship exists.
Funding This work was supported in part by a research grant from the Japan Intractable Disease Research Foundation and by a Grant-in-Aid for Scientific Research C (18K0752) from the Japan Society for the Promotion of Science, Japan.
Competing interests NI has received research support from Mitsubishi Tanabe Pharma, Osoegawa Neurology Clinic, and Japan Blood Products Organization, honoraria from Mitsubishi Tanabe Pharma and Alexion, and is a consultant for Oxford Health Policy Forum CIC.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.