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Research paper
Validation of the revised classification of cognitive and behavioural impairment in ALS
  1. Barbara Iazzolino1,
  2. Debora Pain2,
  3. Laura Peotta1,
  4. Andrea Calvo1,3,
  5. Cristina Moglia1,3,
  6. Antonio Canosa1,
  7. Umberto Manera1,
  8. Antonio Ilardi1,
  9. Alessandro Bombaci1,
  10. Jean Pierre Zucchetti1,
  11. Gabriele Mora2,
  12. Adriano Chio1,2,3
  1. 1 ALS Center, ‘Rita Levi Montalcini’ Department of Neuroscience, University of Turin, Torino, Italy
  2. 2 ALS Center, Istituti Clinici Scientifici Maugeri IRCCS, Milan, Italy
  3. 3 Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy
  1. Correspondence to Professor Adriano Chio, ‘Rita Levi Montalcini’ Department of Neuroscience, Torino I-10126, Italy; achio{at}usa.net

Footnotes

  • GM and AC contributed equally.

  • Contributors Study concept and design: BI, DP, CM, ACalvo, GM, AChio. Analysis and interpretation of data: BI, DP, GM, AChio. Drafting of the manuscript: GM, AChio. Critical revision of the manuscript for important intellectual content: BI, DP, LP, ACalvo, CM, ACanosa, UM, AI, AB, JPZ, GM, AChio. Obtained funding: AChio. Administrative, technical and material support: LP, ACalvo, CM, ACanosa, UM, AI, AB, JPZ. Study supervision: GM, AChio. AChio has full access to data. The corresponding author confirm that all authors have read and approved the final draft of the manuscript and given written permission to include their names in the manuscript.

  • Funding This work was in part supported by the Italian Ministry of Health (Ministero della Salute, Ricerca Sanitaria Finalizzata 2010, grants RF-2010-2309849, RF-2011-02351193 and GR-2011-02351217), the European Commission’s Health Seventh Framework Programme (FP7/2007-2013 under grant agreement 259867) and the Joint Programme—Neurodegenerative Disease Research (Strength, ALS-Care and Brain-Mend projects), granted by Italian Ministry of Education, University and Research. This study was performed under the Department of Excellence grant of the Italian Ministry of Education, University and Research to the ‘Rita Levi Montalcini’ Department of Neuroscience, University of Torino, Italy.

  • Competing interests AC serves on scientific advisory boards for Mitsubishi Tanabe, Roche and Cytokinetics and has received a research grant from Italfarmaco. Andrea Calvo has received research grant from Cytokinetics.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • GM and AC contributed equally.

  • Contributors Study concept and design: BI, DP, CM, ACalvo, GM, AChio. Analysis and interpretation of data: BI, DP, GM, AChio. Drafting of the manuscript: GM, AChio. Critical revision of the manuscript for important intellectual content: BI, DP, LP, ACalvo, CM, ACanosa, UM, AI, AB, JPZ, GM, AChio. Obtained funding: AChio. Administrative, technical and material support: LP, ACalvo, CM, ACanosa, UM, AI, AB, JPZ. Study supervision: GM, AChio. AChio has full access to data. The corresponding author confirm that all authors have read and approved the final draft of the manuscript and given written permission to include their names in the manuscript.

  • Funding This work was in part supported by the Italian Ministry of Health (Ministero della Salute, Ricerca Sanitaria Finalizzata 2010, grants RF-2010-2309849, RF-2011-02351193 and GR-2011-02351217), the European Commission’s Health Seventh Framework Programme (FP7/2007-2013 under grant agreement 259867) and the Joint Programme—Neurodegenerative Disease Research (Strength, ALS-Care and Brain-Mend projects), granted by Italian Ministry of Education, University and Research. This study was performed under the Department of Excellence grant of the Italian Ministry of Education, University and Research to the ‘Rita Levi Montalcini’ Department of Neuroscience, University of Torino, Italy.

  • Competing interests AC serves on scientific advisory boards for Mitsubishi Tanabe, Roche and Cytokinetics and has received a research grant from Italfarmaco. Andrea Calvo has received research grant from Cytokinetics.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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