Footnotes

• Contributors Design of the work: CG-S. Patient data: CG-S, PG, RP, IO, LVD, RM-F, JM-M, DM-M, FA-F. Focused ultrasound: RM-F, FH-F, JAP-P, MdA, RR-R, EdL. Analysis: CG-S. Interpretation of data for the work: CG-S, PG, IO, JAO. Drafting the work: CG-S. Revising the work critically for important intellectual content: all authors. Final approval of the version to be published: JAO.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Patient consent for publication Obtained.

• Ethics approval The Local Ethics Committee for Medical Research approved the study.

• Provenance and peer review Not commissioned; externally peer reviewed.