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Contributors GM and YN contributed equally in the conception of the manuscript, the acquisition of the data and drafting of a significant portion of the manuscript, tables and figures. JAC contributed in drafting and editing a significant portion of the manuscript. SS contributed in the analysis of the data and drafting a significant portion of the manuscript and tables. All authors approved the final manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests GM received fellowship funding from the National Multiple Sclerosis Society Institutional Clinician Training Award ICT 0002 and Biogen Fellowship Grant 6873-P-FEL. SS has nothing to disclose. JAC received personal fees for consulting for Adamas, Alkermes, Convelo, EMD Serono, Novartis and Pendopharm; speaking for Mylan and Synthon; and serving as a Co-Editor of Multiple Sclerosis Journal—Experimental, Translational and Clinical. YN received speech honoraria from Actelion and Orphan Europe, and received travel funding from Actelion, Shire and Genzyme.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.