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Contributors All authors have made substantial contributions to the conception or design of the work, or the acquisition, analysis or interpretation of data, drafting the work or revising it critically for important intellectual content. All have given final approval of the version published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Individual author roles: CF: organisation and execution of research project, design and execution of statistical analysis, writing of the first draft of manuscript; AJE, AEL, TL, DM, FM, NPQ, MV: execution of research project, review and critique of manuscript; AF: conception and organisation of research project, execution of statistical analysis, review and critique of manuscript.
Funding AJE: Consultancies in Abbvie, TEVA, Impax, Acadia, Acorda, Cynapsus/Sunovion, Lundbeck and USWorldMeds, Expert Testimony, Advisory Boards, in Abbvie, TEVA, Impax, Acadia, Cynapsus/Sunovion, Lundbeck and USWorldMeds, Honoraria in Abbvie, UCB, USWorldMeds, Lundbeck, Acadia, Royalties in Lippincott Williams & Wilkins, Cambridge University Press, Springer, Grants in NIH, Great Lakes Neurotechnologies and Michael J Fox Foundation; AF: Consultancies in Abbvie, Medtronic, Boston Scientific, Sunovion, Chiesi farmaceutici, UCB, Ipsen, Advisory Boards in Abbvie, Boston Scientific, Ipsen, Honoraria in Abbvie, Medtronic, Boston Scientific, Sunovion, Chiesi farmaceutici, UCB, Ipsen, Grants University of Toronto, Weston foundation, Abbvie, Medtronic, Boston Scientific.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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