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CNS phenotype in X linked Charcot- Marie-Tooth disease
  1. Vinojini Vivekanandam1,
  2. Chandrashekar Hoskote2,
  3. Alexander M Rossor1,
  4. Mary M Reilly1
  1. 1 MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, UK
  2. 2 Department of Radiology, National Hospital for Neurology and Neurosurgery, London, UK
  1. Correspondence to Dr Vinojini Vivekanandam, MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London WC1N 3BG, UK; vinojini.vivekanandam{at}

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We read with interest the study by Koutsis et al reporting an increased prevalence of multiple sclerosis (MS) in their cohort of patients with X linked Charcot-Marie-Tooth disease (CMTX1).1 CMTX1 is a neurological condition with significant disability. The suggestion that CMTX1 may be a risk factor for developing MS will be of significant concern for these patients.

We have a large cohort of patients with CMTX1 (n=133) in our centre. We reviewed the clinical records and MRI brains in our cohort to look for a similar association.

Patients with confirmed GJB1 mutations were identified from our internal database of individuals with CMT seen in the peripheral neuropathy …

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  • Contributors VV: acquisition, interpretation of data, draft of first manuscript. CH: interpretation of data and revision of manuscript. AMR and MMR: study concept, interpretation of data and revision of manuscript.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval University College London Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.