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We read with interest the study by Koutsis et al reporting an increased prevalence of multiple sclerosis (MS) in their cohort of patients with X linked Charcot-Marie-Tooth disease (CMTX1).1 CMTX1 is a neurological condition with significant disability. The suggestion that CMTX1 may be a risk factor for developing MS will be of significant concern for these patients.
We have a large cohort of patients with CMTX1 (n=133) in our centre. We reviewed the clinical records and MRI brains in our cohort to look for a similar association.
Patients with confirmed GJB1 mutations were identified from our internal database of individuals with CMT seen in the peripheral neuropathy …
Contributors VV: acquisition, interpretation of data, draft of first manuscript. CH: interpretation of data and revision of manuscript. AMR and MMR: study concept, interpretation of data and revision of manuscript.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval University College London Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.