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Longitudinal (18F)AV-1451 PET imaging in a patient with frontotemporal dementia due to a Q351R MAPT mutation

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  • Contributors JDR, RC and JJ designed this study, analysed the data and wrote the manuscript. MC, KM, CK, IOCW, PW, RG, IR, DC, MR, JDW, NCF, SO and MB helped with data collection, analysis and review of the manuscript.

  • Funding The Dementia Research Centre is supported by Alzheimer's Research UK, Brain Research Trust and The Wolfson Foundation. This work was supported by the NIHR Queen Square Dementia Biomedical Research Unit and the NIHR UCL/H Biomedical Research Centre, the MRC UK GENFI grant (MR/M023664/1) and the Alzheimer’s Society (AS-PG-16-007). This work was conducted using the MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1). JDR is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). JDW was supported by a Wellcome Trust Senior Clinical Fellowship (091673/Z/10/Z) and his research is supported by the Alzheimer’s Society, Alzheimer’s Research UK and by the NIHR UCLH Biomedical Research Centre. NCF acknowledges support from the UK Dementia Research Institute at UCL. IOCW was funded by an MRC Clinical Research Training Fellowship (MR/M018288/1). Research Councils UK > Medical Research Council 520874.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the local ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.