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Accounting for genetics and environment to forecast Parkinson’s disease risk
Complex disorders typically result from a combined interplay between genes and environment. However, most studies take either an epidemiological or a genetic approach to understanding risk factors, rarely considering both elements together. In this issue, Jacobs et al 1 report a multimodal approach to uncover the factors that modify the risk of developing Parkinson’s disease (PD). To achieve this, they exploit the UK Biobank database, which includes genetic, lifestyle and health data collected from ~500 000 volunteers in the UK. Furthermore, they evaluate the interaction of genetic and environmental influences through the application of a Polygenic Risk Score (PRS), …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.
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