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Chronic polyradiculoneuro­pathies responsive to immunotherapy do not necessarily show electrophysiologic­al or nerve biopsy evidence of demyelination
  1. John Pollard
  1. Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia
  1. Correspondence to Professor John Pollard, Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia; john.pollard{at}

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In the identification of treatment responsive inflammatory neuropathy, clinical features often play a major role and should guide appropriate investigations

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) remains one of the most satisfying disorders to diagnose since many patients respond well to therapy, and even severely disabled patients may return to normal productive life. This diagnosis is therefore always considered in the investigation of chronic neuropathies. The cardinal feature in diagnosing CIDP has been the demonstration, in the appropriate clinical setting, of electrophysiological features of demyelination. In this issue, Oh et al,1 page…… describe 33 patients with chronic neuropathy in whom no evidence of demyelination was found by electrophysiology or nerve biopsy but rather features of axonal degeneration, yet all responded to immunotherapy. The patients were …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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